Left on the doorstep of an orphanage run by nuns, three newborn knuckleheads grow up to be finger-poking, nyuk-nyuking janitors named Larry, Curly and Moe. When they learn that financial problems will soon force the only home they've ever known to close, the trio sets out to raise $830,000 in one month. Out in the world for the very first time, the three innocent bumblers become embroiled in a murder plot and find stardom on a TV reality show.
A gang of thieves break into a top secret government research centre and steal a deadly virus. Mach 1, a top secret special operations team, is called in to recover it. The team, lead by Commander Bill McNeil (Steve Guttenberg), boards the thieves' plane midflight and recovers the virus. When two members of the team are subsequently murdered, McNeil suspects that the thieves might have inside help. In an attempt to track down who was responsible, the team steals the virus in a hope that the thieves will come after them.
A tribute to the Three Stooges comedy team, featuring old clips and home movies mixed with music performances of Stooge-themed songs.
