The 17th century. Somewhere in the Mexican mountains, a Catholic friar who has fallen victim to a strange disease is carried by his native disciple to the home of an indigenous healer. The old woman will try to cure him by performing an ancient ritual that will have unexpected effects in the body and mind of the evangelist.
Juana is a 15-year-old indigenous girl who lives in the Altiplano, whose older sister Marisol is captured by a human trafficking network. Juana makes a pact with 'The Beheaders,' two cursed spirits that take the form of two machetes. The power of the machetes will transform Juana into 'The Shadow of the Altiplano,' a vengeance-thirsty antiheroine who seeks to rescue her sister and eradicate the abusers of the region.
