Minato zaczyna się dziwnie zachowywać. Gdy zauważa to jego matka, Saori, kobieta postanawia przyjrzeć się bliżej sytuacji dziecka. Wkrótce odkrywa, że jej syn ma problemy ze swoim wychowawcą klasowym, Horim. Saori po śmierci męża samotnie wychowuje nastoletniego syna Minato.
Nueno Mesuke, better known as Nube, is a school teacher who does more than just teach. You see, Nube's left hand is a huge, nasty-looking demon's claw. He uses it to get rid of malicious demons, ghosts, spirits and other supernatural beings that are giving his students a hard time. Nube's left hand was normal, until one fateful day when he exorcised an extremely powerful demon from a child. He was outmatched and lost his left hand. The only way to fight it was to let it enter his body. As a result, Nube has a demonic left hand where his own hand used to be. To educate and protect — that is what Jigoku Sensei Nube does.
