Na Detroit do futuro o crime e a violência tomam conta da cidade. O Oficial Alex J. Murphy, ferido mortalmente em trabalho, retornará como um ciborgue praticamente indestrutível, uma arma da polícia conta os criminosos. Mas lembranças do seu passado acabam atormentando suas funções.
Humans that have been physically altered and turned into dangerous weapons are known as the Extended. Juuzou Inui awakens as one of these weapons — with amnesia. But his job as an agent investigating the Extended leads to a mysterious child with Extended ties showing up at his office. Now Inui must keep the child away from street gangs and the megacorporation Berühren, and it won't be easy.
