Honey Kisaragi uma estudante com uma vida normal até o dia em que seu pai, o Prof. Kisaragi, é morto pela organização criminosa Garra de Pantera 'Panther Claw'. Porém Kisaragi, antes da sua morte, deixa um recado revelando que Honey é na verdade uma androide criada por ele. Ao dizer "Honey Flash!", ela pode se transformar numa guerreira de cabelos vermelhos e usar diversos disfarces, graças ao Air-System, um dispositivo que materializa objetos.
No final do Século 21, o mundo é atormentado por um vírus misterioso e clima incomum. O genial cientista Dr. Kisaragi (Kouichi Iwaki) cria uma ginóide com o nome de código "Cutie Honey" (Mariya Nishiuchi). A ginóide é a única que possui emoções humanas. Para salvar a humanidade, Cutie Honey luta contra uma organização do mal. Baseado no mangá Cutie Honey (1973), de Go Nagai.
Uma noite, um indivíduo que transporta uma pasta é atacado por bandidos mascarados. Cutey Honey salva-o por pouco. A pasta do homem, um arqueólogo, contém uma estranha crisálida que ele roubou a organização Garra de Pantera 'Panther Claw'. Esta borboleta, originária do México e extinta há 6000 anos, é segundo a lenda um anjo da guarda, ajuda os homens a chegarem ao paraíso. A organização Garra de Pantera 'Panther Claw' tenta recuperar a pasta, mas falham novamente... No entanto, conseguem raptar o melhor amigo de Cutey Honey. Para o salvar, a nossa heroína acompanhará o arqueólogo até à América Central seguindo os passos de uma antiga civilização, onde luta contra os insectóides e acaba por ficar numa floresta cheia de borboletas verdes brilhantes.
Num futuro próximo, a organização Garra de Pantera 'Panther Claw' destrói o Governo Metropolitano de Tóquio. O governo da capital é forçado a mudar-se para a província. Durante este período, Honey Kisaragi transferiu-se para a Academia Santa Capela como parte de um curso especial. Este curso especial é o projeto “Nova Geração Honey”, onde os alunos, incluindo Honey, se tornam Cutie Honey.
Honey Kisaragi is a high school student at Sainte Chapelle Girls' School. On her 16th birthday, when she returns home, she discovers that her father Takeshi Kisaragi has been kidnapped by the Panther Claw gang because he had discovered a device that could allow the transformation of the human body. That same evening, Honey Kisaragi meets a man with long white hair who gives her the said device. She thus becomes Cutie Honey and fights Panther Claw to save her father. But a new transfer student, Seira Hazuki, will not make her task easy...
One day, Honey Kisaragi's a trendy, class-cutting Catholic schoolgirl. The next, her father's been murdered by demonic divas from a dastardly organization called Panther Claw. When his dying message reveals that she's an android, Honey uses the transformative power of the Atmospheric Element Solidifier - the very thing Panther Claw wanted to steal - to seek revenge against the shadowy clan.
The forces of evil were looking for trouble; they found Cutey! In a futuristic world were evil comes in all shapes and sizes, she is the ultimate weapon. She's Cutey Honey, a one woman S.W.A.T. team whose android chassis is capable of changing at will into a dazzling array of hard-hitting, curvaceous bodies each with it's own set of special skills, weapons and other impressive physical attributes. Go Nagai's legendary android super-hero is back and hitting the bad guys where it hurts most.
A mysterious organization known as Panther Claw make their presence known by terrorizing Tokyo and giving the cops a run for their money. Police are further baffled by the appearance of a lone cosplaying vigilante who thwarts all of Panther Claw's evil schemes before disappearing. That cosplayer is Honey Kisaragi, the result of the late Professor Kisaragi's prize experiment. A master of disguise, Honey can instantly alter her physical appearance and outfits. But with a push of the heart-shaped button on her choker, she transforms herself into Cutie Honey, the scantily clad, sword-wielding warrior of love and justice.
The Panther Claw organization is driven by a relentless pursuit of wealth, using any means necessary to achieve their goals. However, their plans start to unravel thanks to the unexpected interference of a seemingly ordinary girl. This girl, who initially encounters Panther Claw by chance, turns out to be Kisaragi Honey, the ‘daughter’ of the brilliant cyberneticist Dr. Kisaragi Koshirou. Recognizing her value, Panther Claw’s four members race to capture Cutie Honey. Kisaragi Honey, also known as Cutie Honey, is not alone in her fight. She is joined by two allies, Saotome Miki (Sister Miki) and Kenmochi Yuki (Sister Yuki). Together, they work to thwart Panther Claw’s schemes and protect Honey from being exploited.
Honey Kisaragi is an amazingly humanlike and fashion conscious android with the unique ability to transform her body into a wide range of outrageous yet stylish disguises, each of which comes with its own dazzling super ability. After a run-in with a sinister secret criminal cabal organization, Panther Claw, the luscious and law-abiding Honey makes it her mission to bring them down.
