Quando o seu jovem filho Minato começa a comportar-se de forma estranha, a mãe sente que há algo de errado. Descobrindo que um professor é o responsável, ela invade a escola exigindo saber o que está a acontecer. Mas à medida que a história se desenrola através dos olhos da mãe, do professor e da criança, a verdade vai-se revelando gradualmente.
Nueno Mesuke, better known as Nube, is a school teacher who does more than just teach. You see, Nube's left hand is a huge, nasty-looking demon's claw. He uses it to get rid of malicious demons, ghosts, spirits and other supernatural beings that are giving his students a hard time. Nube's left hand was normal, until one fateful day when he exorcised an extremely powerful demon from a child. He was outmatched and lost his left hand. The only way to fight it was to let it enter his body. As a result, Nube has a demonic left hand where his own hand used to be. To educate and protect — that is what Jigoku Sensei Nube does.
