The Grim Adventures of Billy and Mandy - Season 4 Episode 19 Runaway Pants

At school it is time for the "Presidents Fitness Test", but Billy is absolutely unfit for exercise. On the other hand, Nergal Junior uses his shape-shifting powers to become fit at will and excel in every test. Billy asks Junior to transform into a pair of pants that he can wear, so he can run fast and win the 50-meter race. Since Junior has never attempted to transform into inanimate objects he cannot stop running and cannot revert to his human form. Billy keeps running forever while he becomes a national sensation known as the "Fitness Lad". It is revealed that the story was just all a fabrication created by the narrator, who parodies The Twilight Zone.